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Crystal structure of the mycobacterium tuberculosis antigen 85A protein

Analyse Crystal structure of the mycobacterium tuberculosis antigen 85A protein in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1SFR
Type: protein
Length: 854 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Antigen 85-a
EC: 2.3.1.-
UniProt: P0A4V2
Pockets: 7 · best druggability 0.77

Structure

x-ray diffraction · 2 distinct chains · 38% helix, 20% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Antigen 85-a (EC 2.3.1.-)	protein	288	37% helix, 21% strand	P0A4V2
C	Antigen 85-a (EC 2.3.1.-)	protein	278	38% helix, 20% strand	P0A4V2

Pockets

7 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	663	0.77	0.82	74	empty
2	245	0.64	0.82	32	empty
3	213	0.61	0.81	31	empty
4	416	0.57	0.74	67	empty
5	198	0.57	0.80	26	empty

Interfaces

2 interfaces between chains.

A–B · 843 Å² buried · 0 hydrogen bonds · protein-protein
A–C · 569 Å² buried · 6 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 3 disulfide (disulfide).

Compared structures

1SFR · Crystal Structure of the Mycobacterium tuberculosis Antigen 85A Protein · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P0A4V2
Elsewhere: RCSB PDB 1SFR · PDBe 1SFR · UniProt P0A4V2

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