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Crystal structure of an anti-hcg Fab

Analyse Crystal structure of an anti-hcg Fab in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1SBS
Type: protein
Length: 442 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Monoclonal antibody 3A2
Ligands: SO4
Pockets: 7 · best druggability 0.58

Structure

x-ray diffraction · 2 distinct chains · 7% helix, 52% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
H	Monoclonal antibody 3A2	protein	222	8% helix, 52% strand	—
L	Monoclonal antibody 3A2	protein	220	6% helix, 52% strand	—

Ligands and binding sites

SO4 · Sulfate ion · ion · chains H, L

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	343	0.58	0.76	38	empty
2	373	0.53	0.73	51	empty
3	74	0.47	0.83	22	empty
4	113	0.40	0.76	22	empty
5	60	0.40	0.80	17	empty

Interfaces

1 interface between chains.

H–L · 1771 Å² buried · 14 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

1SBS · Crystal structure of an anti-hcg Fab · the same entry in another collection · chain H against H, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 1SBS · PDBe 1SBS

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