Research workbench
Crystal structure of adeno-associated virus type 2 REP40
Analyse Crystal structure of adeno-associated virus type 2 REP40 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1S9H
- Type
- protein
- Length
- 734 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Rep 40 protein
- Pockets
- 9 · best druggability 0.66
Structure
x-ray diffraction · 3 distinct chains · 40% helix, 11% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Rep 40 protein | protein | 268 | 40% helix, 13% strand | — |
| B | Rep 40 protein | protein | 267 | 40% helix, 15% strand | — |
| C | Rep 40 protein | protein | 199 | 41% helix, 5% strand | — |
Pockets
9 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 510 | 0.66 | 0.78 | 63 | empty |
| 2 | 182 | 0.56 | 0.80 | 35 | empty |
| 3 | 134 | 0.41 | 0.75 | 25 | empty |
| 4 | 86 | 0.39 | 0.77 | 14 | empty |
| 5 | 66 | 0.38 | 0.79 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 904 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 1S9H · Crystal Structure of Adeno-associated virus Type 2 Rep40 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 1S9H · PDBe 1S9H
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