Research workbench
Fab (lnkb-2) of monoclonal antibody to human interleukin-2, crystal structure
Analyse Fab (lnkb-2) of monoclonal antibody to human interleukin-2, crystal structure in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1S5I
- Type
- protein
- Length
- 439 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fab-fragment of monoclonal antibody
- UniProt
- P01869
- Pockets
- 5 · best druggability 0.53
Structure
x-ray diffraction · 2 distinct chains · 6% helix, 51% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| L | Fab-fragment of monoclonal antibody | protein | 219 | 6% helix, 53% strand | — |
| H | Fab-fragment of monoclonal antibody | protein | 220 | 5% helix, 50% strand | P01869 |
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 368 | 0.53 | 0.73 | 46 | empty |
| 2 | 168 | 0.51 | 0.78 | 32 | empty |
| 3 | 159 | 0.47 | 0.76 | 19 | empty |
| 4 | 75 | 0.30 | 0.73 | 16 | empty |
| 5 | 60 | 0.30 | 0.75 | 15 | empty |
Interfaces
1 interface between chains.
- L–H · 2022 Ų buried · 25 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 5 disulfide (disulfide).
Compared structures
- 1S5I · Fab (LNKB-2) of monoclonal antibody to Human Interleukin-2, crystal structure · the same entry in another collection · chain L against L, TM-score 1.00
- P01869 · AlphaFold monomer V2.0 prediction for ig gamma-1 chain C region, membrane-bound form… · a predicted model of the same protein · chain H against A, TM-score 0.51
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P01869
- Elsewhere: RCSB PDB 1S5I · PDBe 1S5I · UniProt P01869
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