Research workbench
Potassium channel kcsa-Fab complex T75C mutant in K+
Analyse Potassium channel kcsa-Fab complex T75C mutant in K+ in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1S5H
- Type
- protein
- Length
- 533 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Antibody Fab fragment light chain; Antibody Fab fragment heavy chain; Voltage-gated…
- UniProt
- Q54397
- Ligands
- F09, DGA, K
- Pockets
- 5 · best druggability 0.66
Structure
x-ray diffraction · 3 distinct chains · 19% helix, 41% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Antibody Fab fragment light chain | protein | 211 | 6% helix, 50% strand | — |
| B | Antibody Fab fragment heavy chain | protein | 219 | 5% helix, 50% strand | — |
| C | Voltage-gated potassium channel | protein | 103 | 74% helix, 0% strand | Q54397 |
Ligands and binding sites
- F09 · Nonan-1-ol · ligand · chains B, C
- DGA · Diacyl glycerol · ligand · chains C
- K · Potassium ion · metal · 7 copies · chains C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 696 | 0.66 | 0.75 | 59 | empty |
| 2 | 67 | 0.55 | 0.88 | 20 | empty |
| 3 | 73 | 0.47 | 0.83 | 16 | empty |
| 4 | 123 | 0.46 | 0.78 | 21 | empty |
| 5 | 76 | 0.32 | 0.74 | 16 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1759 Ų buried · 17 hydrogen bonds · protein-protein
- B–C · 489 Ų buried · 8 hydrogen bonds · protein-protein
- A–C · 438 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 1S5H · Potassium Channel Kcsa-Fab Complex T75C mutant in K+ · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q54397
- Elsewhere: RCSB PDB 1S5H · PDBe 1S5H · UniProt Q54397
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