Research workbench
Crystal structure of RNA-dependent RNA polymerase construct 1 (residues 71-679) from bvdv
Analyse Crystal structure of RNA-dependent RNA polymerase construct 1 (residues 71-679)… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1S48
- Type
- protein
- Length
- 588 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- RNA-dependent RNA polymerase
- UniProt
- P19711
- Pockets
- 9 · best druggability 0.68
Structure
x-ray diffraction · 1 distinct chain · 43% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | RNA-dependent RNA polymerase | protein | 588 | 43% helix, 15% strand | P19711 |
Pockets
9 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 288 | 0.68 | 0.83 | 32 | empty |
| 2 | 261 | 0.64 | 0.81 | 27 | empty |
| 3 | 151 | 0.57 | 0.82 | 24 | empty |
| 4 | 189 | 0.56 | 0.80 | 32 | empty |
| 5 | 141 | 0.53 | 0.81 | 33 | empty |
Modifications
Observed in the structure: 12 modified (engineered).
Compared structures
- 1S48 · Crystal structure of RNA-dependent RNA polymerase construct 1 (residues 71-679) from BVDV · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P19711
- Elsewhere: RCSB PDB 1S48 · PDBe 1S48 · UniProt P19711
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