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Crystal structure of botulinum neurotoxin type B apo form

Analyse Crystal structure of botulinum neurotoxin type B apo form in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1S0G
Type: protein
Length: 1,288 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Botulinum neurotoxin type B
EC: 3.4.24.69
UniProt: P10844
Pockets: 12 · best druggability 0.80

Structure

x-ray diffraction · 1 distinct chain · 32% helix, 25% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Botulinum neurotoxin type B (EC 3.4.24.69)	protein	1288	32% helix, 25% strand	P10844

Pockets

12 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	863	0.80	0.82	71	empty
2	336	0.77	0.88	51	empty
3	398	0.69	0.81	46	empty
4	350	0.67	0.81	36	empty
5	425	0.62	0.76	37	empty

Compared structures

1S0G · Crystal structure of botulinum neurotoxin type B apo form · the same entry in another collection · chain A against A, TM-score 1.00
P10844 · AlphaFold monomer V2.0 prediction for botulinum neurotoxin type B (P10844) · a predicted model of the same protein · chain A against A, TM-score 0.67

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P10844
Elsewhere: RCSB PDB 1S0G · PDBe 1S0G · UniProt P10844

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