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Solution structure of human prolactin

Analyse Solution structure of human prolactin in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1RW5
Type: protein
Length: 199 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Prolactin
UniProt: P01236
Pockets: 1 · best druggability 0.46

Structure

solution nmr · 1 distinct chain · 62% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Prolactin	protein	199	62% helix, 0% strand	P01236

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	161	0.46	0.76	17	empty

Modifications

Observed in the structure: 3 disulfide (disulfide).

Compared structures

1RW5 · Solution structure of human prolactin · the same entry in another collection · chain A against A, TM-score 1.00
P01236 · AlphaFold monomer V2.0 prediction for prolactin (P01236) · a predicted model of the same protein · chain A against A, TM-score 0.88

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P01236
Elsewhere: RCSB PDB 1RW5 · PDBe 1RW5 · UniProt P01236

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