Research workbench
Close packing of an oligomeric eye lens beta-crystallin induces loss of symmetry and ordering of sequence extensions
Analyse Close packing of an oligomeric eye lens beta-crystallin induces loss of… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1BLB
- Type
- protein
- Length
- 736 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Beta B2-crystallin
- UniProt
- P02522
- Pockets
- 3 · best druggability 0.27
Structure
x-ray diffraction · 4 distinct chains · 5% helix, 33% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Beta B2-crystallin | protein | 185 | 4% helix, 29% strand | P02522 |
| B | Beta B2-crystallin | protein | 181 | 6% helix, 31% strand | P02522 |
| C | Beta B2-crystallin | protein | 187 | 6% helix, 34% strand | P02522 |
| D | Beta B2-crystallin | protein | 183 | 4% helix, 39% strand | P02522 |
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 58 | 0.27 | 0.74 | 13 | empty |
| 2 | 60 | 0.26 | 0.72 | 15 | empty |
| 3 | 53 | 0.24 | 0.72 | 15 | empty |
Interfaces
3 interfaces between chains.
- C–D · 2137 Ų buried · 34 hydrogen bonds · protein-protein
- A–B · 2086 Ų buried · 29 hydrogen bonds · protein-protein
- A–D · 90 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 1BLB · Close packing of an oligomeric eye lens beta-crystallin induces loss of symmetry and… · the same entry in another collection · chain D against D, TM-score 1.00
- P02522 · AlphaFold monomer V2.0 prediction for beta-crystallin B2 (P02522) · a predicted model of the same protein · chain C against A, TM-score 0.48
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P02522
- Elsewhere: RCSB PDB 1BLB · PDBe 1BLB · UniProt P02522
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.