Research workbench
Structure and mechanism of mRNA cap (guanine N-7) methyltransferase
Analyse Structure and mechanism of mRNA cap (guanine N-7) methyltransferase in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1RI5
- Type
- protein
- Length
- 252 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- MRNA capping enzyme
- UniProt
- Q8SR66
- Pockets
- 3 · best druggability 0.63
Structure
x-ray diffraction · 1 distinct chain · 38% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | MRNA capping enzyme | protein | 252 | 38% helix, 27% strand | Q8SR66 |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 442 | 0.63 | 0.76 | 42 | empty |
| 2 | 63 | 0.33 | 0.76 | 13 | empty |
| 3 | 51 | 0.28 | 0.75 | 14 | empty |
Compared structures
- 1RI5 · Structure and mechanism of mRNA cap (guanine N-7) methyltransferase · the same entry in another collection · chain A against A, TM-score 1.00
- Q8SR66 · AlphaFold monomer V2.0 prediction for mRNA cap guanine-N7 methyltransferase (Q8SR66) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8SR66
- Elsewhere: RCSB PDB 1RI5 · PDBe 1RI5 · UniProt Q8SR66
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