Research workbench
The structure of granulocyte-colony-stimulating factor and its relationship to those of other growth factors
Analyse The structure of granulocyte-colony-stimulating factor and its relationship to… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1RHG
- Type
- protein
- Length
- 434 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Granulocyte colony-stimulating factor
- UniProt
- P09919
- Pockets
- 5 · best druggability 0.70
Structure
x-ray diffraction · 2 distinct chains · 76% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Granulocyte colony-stimulating factor | protein | 145 | 77% helix, 0% strand | P09919 |
| B | Granulocyte colony-stimulating factor | protein | 144 | 76% helix, 0% strand | P09919 |
Pockets
5 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 62 | 0.70 | 0.97 | 15 | empty |
| 2 | 123 | 0.57 | 0.84 | 23 | empty |
| 3 | 329 | 0.57 | 0.76 | 25 | empty |
| 4 | 192 | 0.55 | 0.79 | 19 | empty |
| 5 | 74 | 0.29 | 0.73 | 13 | empty |
Interfaces
2 interfaces between chains.
- A–C · 873 Ų buried · 13 hydrogen bonds · protein-protein
- B–C · 736 Ų buried · 11 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 1RHG · The structure of granulocyte-colony-stimulating factor and its relationship to those of… · the same entry in another collection · chain B against B, TM-score 1.00
- P09919 · AlphaFold monomer V2.0 prediction for granulocyte colony-stimulating factor (P09919) · a predicted model of the same protein · chain C against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P09919
- Elsewhere: RCSB PDB 1RHG · PDBe 1RHG · UniProt P09919
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