Research workbench
Human acidic fibroblast growth factor (hafgf-1) at 1.10 ångström resolution (140 amino acid form)
Analyse Human acidic fibroblast growth factor (hafgf-1) at 1.10 ångström resolution… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1RG8
- Type
- protein
- Length
- 282 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Heparin-binding growth factor 1
- UniProt
- P05230
- Pockets
- 2 · best druggability 0.43
Structure
x-ray diffraction · 1 distinct chain · 6% helix, 39% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Heparin-binding growth factor 1 | protein | 141 | 6% helix, 39% strand | P05230 |
Ligands and binding sites
- FMT · Formic acid · additive · 5 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 117 | 0.43 | 0.77 | 23 | empty |
| 2 | 80 | 0.30 | 0.73 | 21 | empty |
Interfaces
1 interface between chains.
- A–B · 454 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
- 1RG8 · Human Acidic Fibroblast Growth Factor (haFGF-1) at 1.10 angstrom resolution (140 amino… · the same entry in another collection · chain A against A, TM-score 1.00
- P05230 · AlphaFold monomer V2.0 prediction for fibroblast growth factor 1 (P05230) · a predicted model of the same protein · chain B against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P05230
- Elsewhere: RCSB PDB 1RG8 · PDBe 1RG8 · UniProt P05230
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