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Crystal structure of the C-terminal WD40 domain of SIF2

Analyse Crystal structure of the C-terminal WD40 domain of SIF2 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1R5M
Type: protein
Length: 351 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: SIR4-interacting protein SIF2
UniProt: P38262
Ligands: SO4
Pockets: 2 · best druggability 0.77

Structure

x-ray diffraction · 1 distinct chain · 2% helix, 54% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	SIR4-interacting protein SIF2	protein	351	2% helix, 54% strand	P38262

Ligands and binding sites

SO4 · Sulfate ion · ion · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1022	0.77	0.79	56	SO4
2	56	0.40	0.80	14	empty

Compared structures

1R5M · Crystal Structure Of The C-Terminal WD40 Domain Of Sif2 · the same entry in another collection · chain A against A, TM-score 1.00
P38262 · AlphaFold monomer V2.0 prediction for SIR4-interacting protein SIF2 (P38262) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P38262
Elsewhere: RCSB PDB 1R5M · PDBe 1R5M · UniProt P38262

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