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Crystal structure of a phosphotransacetylase from streptococcus pyogenes

Analyse Crystal structure of a phosphotransacetylase from streptococcus pyogenes in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1R5J
Type: protein
Length: 658 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Putative phosphotransacetylase
EC: 2.3.1.8
UniProt: Q99ZQ5
Pockets: 4 · best druggability 0.66

Structure

x-ray diffraction · 1 distinct chain · 45% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Putative phosphotransacetylase (EC 2.3.1.8)	protein	329	45% helix, 16% strand	Q99ZQ5

Pockets

4 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	472	0.66	0.78	50	empty
2	464	0.66	0.78	46	empty
3	111	0.54	0.83	23	empty
4	112	0.53	0.83	26	empty

Interfaces

1 interface between chains.

A–B · 1579 Å² buried · 9 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 20 modified (engineered).

Compared structures

1R5J · Crystal Structure of a Phosphotransacetylase from Streptococcus pyogenes · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q99ZQ5
Elsewhere: RCSB PDB 1R5J · PDBe 1R5J · UniProt Q99ZQ5

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