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Crystal structure of the bifunctional chorismate synthase from saccharomyces cerevisiae
Analyse Crystal structure of the bifunctional chorismate synthase from saccharomyces… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1R52
- Type
- protein
- Length
- 1,130 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Chorismate synthase
- EC
- 4.2.3.5
- UniProt
- P28777
- Pockets
- 16 · best druggability 0.88
Structure
x-ray diffraction · 3 distinct chains · 36% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Chorismate synthase (EC 4.2.3.5) | protein | 283 | 36% helix, 23% strand | P28777 |
| B, D | Chorismate synthase (EC 4.2.3.5) | protein | 282 | 35% helix, 23% strand | P28777 |
| C | Chorismate synthase (EC 4.2.3.5) | protein | 283 | 36% helix, 23% strand | P28777 |
Pockets
16 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1030 | 0.88 | 0.89 | 85 | empty |
| 2 | 521 | 0.65 | 0.77 | 68 | empty |
| 3 | 389 | 0.63 | 0.78 | 54 | empty |
| 4 | 332 | 0.61 | 0.78 | 49 | empty |
| 5 | 284 | 0.56 | 0.77 | 42 | empty |
Interfaces
6 interfaces between chains.
- C–D · 2390 Ų buried · 32 hydrogen bonds · protein-protein
- A–B · 2357 Ų buried · 30 hydrogen bonds · protein-protein
- B–C · 1126 Ų buried · 15 hydrogen bonds · protein-protein
- A–D · 1119 Ų buried · 19 hydrogen bonds · protein-protein
- B–D · 775 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
- 1R52 · Crystal structure of the bifunctional chorismate synthase from Saccharomyces cerevisiae · the same entry in another collection · chain D against D, TM-score 1.00
- P28777 · AlphaFold monomer V2.0 prediction for chorismate synthase (P28777) · a predicted model of the same protein · chain D against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P28777
- Elsewhere: RCSB PDB 1R52 · PDBe 1R52 · UniProt P28777
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