Research workbench
Crystal structure of hypoxanthine-guanine phosphoribosyltransferase from thermoanaerobacter tengcongensis
Analyse Crystal structure of hypoxanthine-guanine phosphoribosyltransferase from… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1R3U
- Type
- protein
- Length
- 357 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Hypoxanthine-guanine phosphoribosyltransferase
- EC
- 2.4.2.8
- UniProt
- Q8R7L0
- Ligands
- MG
- Pockets
- 4 · best druggability 0.58
Structure
x-ray diffraction · 2 distinct chains · 28% helix, 32% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Hypoxanthine-guanine phosphoribosyltransferase (EC 2.4.2.8) | protein | 179 | 26% helix, 32% strand | Q8R7L0 |
| B | Hypoxanthine-guanine phosphoribosyltransferase (EC 2.4.2.8) | protein | 178 | 30% helix, 33% strand | Q8R7L0 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 323 | 0.58 | 0.76 | 31 | MG, ACT |
| 2 | 317 | 0.56 | 0.76 | 28 | MG |
| 3 | 58 | 0.33 | 0.77 | 9 | empty |
| 4 | 52 | 0.25 | 0.72 | 12 | empty |
Interfaces
1 interface between chains.
- A–B · 840 Ų buried · 26 hydrogen bonds · protein-protein
Compared structures
- 1R3U · Crystal Structure of Hypoxanthine-Guanine Phosphoribosyltransferase from… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8R7L0
- Elsewhere: RCSB PDB 1R3U · PDBe 1R3U · UniProt Q8R7L0
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