Research workbench

Uroporphyrinogen decarboxylase with mutation D86N

Analyse Uroporphyrinogen decarboxylase with mutation D86N in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1R3R
Type: protein
Length: 356 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Uroporphyrinogen decarboxylase
EC: 4.1.1.37
UniProt: P06132
Pockets: 2 · best druggability 0.70

Structure

x-ray diffraction · 1 distinct chain · 53% helix, 11% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Uroporphyrinogen decarboxylase (EC 4.1.1.37)	protein	356	53% helix, 11% strand	P06132

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	459	0.70	0.80	40	empty
2	53	0.24	0.72	14	empty

Compared structures

1R3R · Uroporphyrinogen Decarboxylase with mutation D86N · the same entry in another collection · chain A against A, TM-score 1.00
P06132 · AlphaFold monomer V2.0 prediction for uroporphyrinogen decarboxylase (P06132) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P06132
Elsewhere: RCSB PDB 1R3R · PDBe 1R3R · UniProt P06132

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.