Research workbench
Potassium channel kcsa-Fab complex in low concentration of tl+
Analyse Potassium channel kcsa-Fab complex in low concentration of tl+ in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1R3K
- Type
- protein
- Length
- 534 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Antibody Fab fragment light chain; Antibody Fab fragment heavy chain; Voltage-gated…
- UniProt
- P0A334
- Ligands
- DGA, TL
- Pockets
- 7 · best druggability 0.68
Structure
x-ray diffraction · 3 distinct chains · 17% helix, 39% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Antibody Fab fragment light chain | protein | 212 | 6% helix, 49% strand | — |
| B | Antibody Fab fragment heavy chain | protein | 219 | 1% helix, 48% strand | — |
| C | Voltage-gated potassium channel | protein | 103 | 73% helix, 0% strand | P0A334 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 749 | 0.68 | 0.76 | 63 | empty |
| 2 | 83 | 0.53 | 0.85 | 21 | empty |
| 3 | 59 | 0.50 | 0.86 | 14 | empty |
| 4 | 126 | 0.43 | 0.76 | 24 | empty |
| 5 | 88 | 0.34 | 0.74 | 19 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1798 Ų buried · 17 hydrogen bonds · protein-protein
- A–C · 441 Ų buried · 11 hydrogen bonds · protein-protein
- B–C · 438 Ų buried · 7 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 1R3K · potassium channel KcsA-Fab complex in low concentration of Tl+ · the same entry in another collection · chain A against A, TM-score 1.00
- P0A334 · AlphaFold monomer V2.0 prediction for pH-gated potassium channel kcsa (P0A334) · a predicted model of the same protein · chain C against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0A334
- Elsewhere: RCSB PDB 1R3K · PDBe 1R3K · UniProt P0A334
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