Research workbench
Fab from murine IGG3 kappa
Analyse Fab from murine IGG3 kappa in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1R24
- Type
- protein
- Length
- 846 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein (IGG3-kappa antibody (light chain)); Protein (IGG3-kappa antibody (heavy chain))
- Pockets
- 8 · best druggability 0.65
Structure
x-ray diffraction · 2 distinct chains · 6% helix, 44% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Protein (IGG3-kappa antibody (light chain)) | protein | 206 | 6% helix, 41% strand | — |
| B, D | Protein (IGG3-kappa antibody (heavy chain)) | protein | 217 | 6% helix, 48% strand | — |
Pockets
8 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 56 | 0.65 | 0.95 | 18 | empty |
| 2 | 625 | 0.65 | 0.75 | 65 | empty |
| 3 | 72 | 0.32 | 0.75 | 20 | empty |
| 4 | 90 | 0.32 | 0.72 | 25 | empty |
| 5 | 73 | 0.32 | 0.75 | 21 | empty |
Interfaces
5 interfaces between chains.
- C–D · 1809 Ų buried · 12 hydrogen bonds · protein-protein
- A–B · 1782 Ų buried · 13 hydrogen bonds · protein-protein
- A–C · 145 Ų buried · 3 hydrogen bonds · protein-protein
- A–D · 122 Ų buried · 3 hydrogen bonds · protein-protein
- B–D · 84 Ų buried · 1 hydrogen bond · protein-protein
Modifications
Observed in the structure: 8 disulfide (disulfide).
Compared structures
- 1R24 · Fab from murine IGG3 kappa · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 1R24 · PDBe 1R24
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