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Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor C-met

Analyse Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1R1W
Type: protein
Length: 287 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Hepatocyte growth factor receptor
EC: 2.7.1.112
UniProt: P08581
Pockets: 3 · best druggability 0.60

Structure

x-ray diffraction · 1 distinct chain · 41% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Hepatocyte growth factor receptor (EC 2.7.1.112)	protein	287	41% helix, 17% strand	P08581

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	152	0.60	0.83	22	empty
2	85	0.37	0.76	22	empty
3	63	0.29	0.74	15	empty

Compared structures

1R1W · Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor… · the same entry in another collection · chain A against A, TM-score 1.00
P08581 · AlphaFold monomer V2.0 prediction for hepatocyte growth factor receptor (P08581) · a predicted model of the same protein · chain A against A, TM-score 0.87

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P08581
Elsewhere: RCSB PDB 1R1W · PDBe 1R1W · UniProt P08581

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