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Crystal structure of the complete core of archaeal srp and implications for inter-domain communication

Analyse Crystal structure of the complete core of archaeal srp and implications for… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
1QZX
Type
protein
Length
850 residues
Chains
2
Method
x-ray diffraction
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
Signal recognition 54 kda protein
UniProt
Q97ZE7
Pockets
11 · best druggability 0.78

Structure

x-ray diffraction · 1 distinct chain · 55% helix, 10% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
A, BSignal recognition 54 kda proteinprotein42555% helix, 10% strandQ97ZE7

Pockets

11 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
19500.780.8097empty
211760.770.79109empty
38850.700.7572empty
41440.590.8424empty
51300.490.7923empty

Interfaces

1 interface between chains.

  • A–B · 2092 Ų buried · 40 hydrogen bonds · protein-protein

Compared structures

  • 1QZX · Crystal structure of the complete core of archaeal SRP and implications for inter-domain… · the same entry in another collection · chain A against A, TM-score 1.00
  • Q97ZE7 · AlphaFold monomer V2.0 prediction for signal recognition particle 54 kda protein (Q97ZE7) · a predicted model of the same protein · chain A against A, TM-score 0.93

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