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Phosphotransacetylase from methanosarcina thermophila

Analyse Phosphotransacetylase from methanosarcina thermophila in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1QZT
Type: protein
Length: 1,326 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Phosphate acetyltransferase
EC: 2.3.1.8
UniProt: P38503
Ligands: SO4
Pockets: 12 · best druggability 0.70

Structure

x-ray diffraction · 2 distinct chains · 47% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, D	Phosphate acetyltransferase (EC 2.3.1.8)	protein	332	47% helix, 17% strand	P38503
B, C	Phosphate acetyltransferase (EC 2.3.1.8)	protein	331	47% helix, 16% strand	P38503

Ligands and binding sites

SO4 · Sulfate ion · ion · 11 copies · chains A, B, C, D

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

12 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	513	0.70	0.80	51	SO4
2	231	0.66	0.84	39	SO4
3	477	0.64	0.77	45	SO4
4	438	0.64	0.78	46	SO4
5	251	0.59	0.79	28	empty

Interfaces

2 interfaces between chains.

A–B · 1747 Å² buried · 7 hydrogen bonds · protein-protein
C–D · 1722 Å² buried · 7 hydrogen bonds · protein-protein

Compared structures

1QZT · Phosphotransacetylase from Methanosarcina thermophila · the same entry in another collection · chain A against A, TM-score 1.00
P38503 · AlphaFold monomer V2.0 prediction for phosphate acetyltransferase (P38503) · a predicted model of the same protein · chain B against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P38503
Elsewhere: RCSB PDB 1QZT · PDBe 1QZT · UniProt P38503

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