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The E. COLI biotin holoenzyme SYNTHETASE(SLASH)BIO repressor crystal structure delineates the biotin and DNA- binding domains

Analyse The E. COLI biotin holoenzyme SYNTHETASE(SLASH)BIO repressor crystal structure… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1BIA
Type: protein
Length: 292 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Bira bifunctional protein
EC: 6.3.4.15
UniProt: P06709
Pockets: 2 · best druggability 0.57

Structure

x-ray diffraction · 1 distinct chain · 33% helix, 29% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Bira bifunctional protein (EC 6.3.4.15)	protein	292	33% helix, 29% strand	P06709

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	186	0.57	0.80	25	empty
2	68	0.29	0.74	20	empty

Compared structures

1BIA · The E. COLI biotin holoenzyme SYNTHETASE(SLASH)BIO repressor crystal structure delineates… · the same entry in another collection · chain A against A, TM-score 1.00
P06709 · AlphaFold monomer V2.0 prediction for bifunctional LIGASE/REPRESSOR bira (P06709) · a predicted model of the same protein · chain A against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P06709
Elsewhere: RCSB PDB 1BIA · PDBe 1BIA · UniProt P06709

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