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Crystal structure of the RNA directed RNA polymerase of hepatitis C virus
Analyse Crystal structure of the RNA directed RNA polymerase of hepatitis C virus in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1QUV
- Type
- protein
- Length
- 553 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein (RNA-directed RNA polymerase)
- EC
- 2.7.7.48
- UniProt
- P26663
- Pockets
- 8 · best druggability 0.80
Structure
x-ray diffraction · 1 distinct chain · 48% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein (RNA-directed RNA polymerase) (EC 2.7.7.48) | protein | 553 | 48% helix, 15% strand | P26663 |
Pockets
8 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1083 | 0.80 | 0.81 | 91 | empty |
| 2 | 102 | 0.47 | 0.80 | 19 | empty |
| 3 | 108 | 0.41 | 0.76 | 19 | empty |
| 4 | 71 | 0.40 | 0.79 | 23 | empty |
| 5 | 65 | 0.33 | 0.76 | 19 | empty |
Compared structures
- 1QUV · Crystal structure of the RNA directed RNA polymerase of hepatitis C virus · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P26663
- Elsewhere: RCSB PDB 1QUV · PDBe 1QUV · UniProt P26663
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