Research workbench
Crystal structure of EHA2 (23-185)
Analyse Crystal structure of EHA2 (23-185) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1QU1
- Type
- protein
- Length
- 874 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein (influenza recombinant HA2 chain)
- UniProt
- P03437
- Pockets
- 7 · best druggability 0.48
Structure
x-ray diffraction · 5 distinct chains · 63% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein (influenza recombinant HA2 chain) | protein | 133 | 67% helix, 0% strand | P03437 |
| B | Protein (influenza recombinant HA2 chain) | protein | 144 | 63% helix, 7% strand | P03437 |
| C | Protein (influenza recombinant HA2 chain) | protein | 150 | 61% helix, 1% strand | P03437 |
| D, E | Protein (influenza recombinant HA2 chain) | protein | 146 | 65% helix, 3% strand | P03437 |
| F | Protein (influenza recombinant HA2 chain) | protein | 155 | 60% helix, 4% strand | P03437 |
Pockets
7 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 134 | 0.48 | 0.79 | 22 | empty |
| 2 | 116 | 0.43 | 0.77 | 23 | empty |
| 3 | 110 | 0.42 | 0.77 | 19 | empty |
| 4 | 103 | 0.39 | 0.76 | 19 | empty |
| 5 | 88 | 0.38 | 0.76 | 17 | empty |
Interfaces
6 interfaces between chains.
- D–F · 2410 Ų buried · 31 hydrogen bonds · protein-protein
- D–E · 2354 Ų buried · 33 hydrogen bonds · protein-protein
- B–C · 2315 Ų buried · 33 hydrogen bonds · protein-protein
- E–F · 2293 Ų buried · 32 hydrogen bonds · protein-protein
- A–B · 2263 Ų buried · 29 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 disulfide (disulfide).
Compared structures
- 1QU1 · Crystal structure of EHA2 (23-185) · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03437
- Elsewhere: RCSB PDB 1QU1 · PDBe 1QU1 · UniProt P03437
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