Research workbench
Purine repressor mutant-hypoxanthine-palindromic operator complex
Analyse Purine repressor mutant-hypoxanthine-palindromic operator complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1QQB
- Type
- protein + DNA
- Length
- 355 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 5'-D(*TP*AP*CP*GP*CP*AP*AP*TP*CP*GP*AP*TP*TP*GP*CP*GP*T)- 3'; Purine nucleotide synthesis…
- UniProt
- P0ACP7
- Ligands
- HPA
- Pockets
- 3 · best druggability 0.63
Structure
x-ray diffraction · 2 distinct chains · 46% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| M | 5'-D(*TP*AP*CP*GP*CP*AP*AP*TP*CP*GP*AP*TP*TP*GP*CP*GP*T)- 3' | dna | 17 | — | — |
| A | Purine nucleotide synthesis repressor | protein | 338 | 46% helix, 14% strand | P0ACP7 |
Ligands and binding sites
- HPA · Hypoxanthine · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 141 | 0.63 | 0.85 | 31 | HPA |
| 2 | 175 | 0.42 | 0.73 | 28 | empty |
| 3 | 115 | 0.35 | 0.73 | 15 | empty |
Interfaces
1 interface between chains.
- M–A · 480 Ų buried · 12 hydrogen bonds · protein-nucleic
Compared structures
- 1QQB · Purine repressor mutant-hypoxanthine-palindromic operator complex · the same entry in another collection · chain M against M, TM-score 1.00
- P0ACP7 · AlphaFold monomer V2.0 prediction for hth-type transcriptional repressor purr (P0ACP7) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0ACP7
- Elsewhere: RCSB PDB 1QQB · PDBe 1QQB · UniProt P0ACP7
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