Research workbench
2.0 ångström structure of intact alpha-1-antitrypsin: a canonical template for active serpins
Analyse 2.0 ångström structure of intact alpha-1-antitrypsin: a canonical template for… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1QLP
- Type
- protein
- Length
- 372 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Alpha-1-antitrypsin
- UniProt
- P01009
- Pockets
- 4 · best druggability 0.61
Structure
x-ray diffraction · 1 distinct chain · 29% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Alpha-1-antitrypsin | protein | 372 | 29% helix, 30% strand | P01009 |
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 166 | 0.61 | 0.83 | 24 | empty |
| 2 | 74 | 0.53 | 0.86 | 24 | empty |
| 3 | 93 | 0.37 | 0.75 | 16 | empty |
| 4 | 94 | 0.36 | 0.74 | 23 | empty |
Compared structures
- 1QLP · 2.0 ångström structure of intact alpha-1-antitrypsin: a canonical template for active… · the same entry in another collection · chain A against A, TM-score 1.00
- P01009 · AlphaFold monomer V2.0 prediction for alpha-1-antitrypsin (P01009) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P01009
- Elsewhere: RCSB PDB 1QLP · PDBe 1QLP · UniProt P01009
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