Research workbench
Crystal structure of the Fab fragment from the human myeloma immunoglobulin IgG hil at 1.8 ångströms resolution
Analyse Crystal structure of the Fab fragment from the human myeloma immunoglobulin IgG… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 8FAB
- Type
- protein
- Length
- 848 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- IGG1-lambda hil Fab (light chain); IGG1-lambda hil Fab (heavy chain)
- Pockets
- 6 · best druggability 0.64
Structure
x-ray diffraction · 3 distinct chains · 9% helix, 50% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | IGG1-lambda hil Fab (light chain) | protein | 206 | 8% helix, 52% strand | — |
| B | IGG1-lambda hil Fab (heavy chain) | protein | 214 | 9% helix, 50% strand | — |
| D | IGG1-lambda hil Fab (heavy chain) | protein | 222 | 9% helix, 49% strand | — |
Pockets
6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 581 | 0.64 | 0.75 | 60 | empty |
| 2 | 706 | 0.63 | 0.73 | 61 | empty |
| 3 | 365 | 0.55 | 0.74 | 36 | empty |
| 4 | 181 | 0.43 | 0.74 | 23 | empty |
| 5 | 96 | 0.39 | 0.76 | 25 | empty |
Interfaces
4 interfaces between chains.
- C–D · 1753 Ų buried · 19 hydrogen bonds · protein-protein
- A–B · 1486 Ų buried · 15 hydrogen bonds · protein-protein
- A–C · 174 Ų buried · 0 hydrogen bonds · protein-protein
- B–C · 11 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 8 disulfide (disulfide).
Compared structures
- 8FAB · Crystal structure of the Fab fragment from the human myeloma immunoglobulin IgG hil at… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 8FAB · PDBe 8FAB
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