Research workbench
Crystal structure of the cell cycle regulatory protein CKS1
Analyse Crystal structure of the cell cycle regulatory protein CKS1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1QB3
- Type
- protein
- Length
- 341 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cyclin-dependent kinases regulatory subunit
- UniProt
- P20486
- Pockets
- 3 · best druggability 0.62
Structure
x-ray diffraction · 3 distinct chains · 32% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cyclin-dependent kinases regulatory subunit | protein | 113 | 34% helix, 20% strand | P20486 |
| B | Cyclin-dependent kinases regulatory subunit | protein | 119 | 34% helix, 8% strand | P20486 |
| C | Cyclin-dependent kinases regulatory subunit | protein | 109 | 28% helix, 21% strand | P20486 |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 375 | 0.62 | 0.77 | 46 | empty |
| 2 | 90 | 0.42 | 0.79 | 22 | empty |
| 3 | 65 | 0.28 | 0.73 | 15 | empty |
Interfaces
3 interfaces between chains.
- A–C · 2342 Ų buried · 45 hydrogen bonds · protein-protein
- B–C · 283 Ų buried · 7 hydrogen bonds · protein-protein
- A–B · 93 Ų buried · 4 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 1QB3 · Crystal structure of the cell cycle regulatory protein CKS1 · the same entry in another collection · chain A against A, TM-score 1.00
- P20486 · AlphaFold monomer V2.0 prediction for cyclin-dependent kinases regulatory subunit (P20486) · a predicted model of the same protein · chain C against A, TM-score 0.77
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P20486
- Elsewhere: RCSB PDB 1QB3 · PDBe 1QB3 · UniProt P20486
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.