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Cryo-EM structure of BCL10 R58Q filament

Analyse Cryo-EM structure of BCL10 R58Q filament in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 8CZD
Type: protein
Length: 2,120 residues
Chains: 20
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: B-cell LYMPHOMA/LEUKEMIA 10
UniProt: O95999
Pockets: 20 · best druggability 0.84

Structure

electron microscopy · 1 distinct chain · 72% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
C, Q, R, S, T, A, B, D, E, F, G, H, I, J, K, L, M, N, O, P	B-cell LYMPHOMA/LEUKEMIA 10	protein	106	72% helix, 0% strand	O95999

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	617	0.84	0.89	82	empty
2	763	0.84	0.87	82	empty
3	161	0.81	0.96	35	empty
4	148	0.81	0.97	31	empty
5	124	0.80	0.98	24	empty

Interfaces

65 interfaces between chains.

K–O · 606 Å² buried · 10 hydrogen bonds · protein-protein
F–J · 601 Å² buried · 10 hydrogen bonds · protein-protein
D–H · 599 Å² buried · 10 hydrogen bonds · protein-protein
I–M · 595 Å² buried · 9 hydrogen bonds · protein-protein
L–P · 592 Å² buried · 9 hydrogen bonds · protein-protein

Compared structures

8CZD · Cryo-EM structure of BCL10 R58Q filament · the same entry in another collection · chain G against G, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O95999
Elsewhere: RCSB PDB 8CZD · PDBe 8CZD · UniProt O95999

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