Research workbench
Actin binding region of the dystrophin homologue utrophin
Analyse Actin binding region of the dystrophin homologue utrophin in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1QAG
- Type
- protein
- Length
- 452 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Utrophin actin binding region
- UniProt
- P46939
- Pockets
- 4 · best druggability 0.39
Structure
x-ray diffraction · 1 distinct chain · 64% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Utrophin actin binding region | protein | 226 | 64% helix, 0% strand | P46939 |
Pockets
4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 70 | 0.39 | 0.79 | 14 | empty |
| 2 | 65 | 0.36 | 0.77 | 13 | empty |
| 3 | 76 | 0.34 | 0.75 | 20 | empty |
| 4 | 57 | 0.30 | 0.75 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 2563 Ų buried · 32 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 10 modified (engineered).
Compared structures
- 1QAG · Actin binding region of the dystrophin homologue utrophin · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P46939
- Elsewhere: RCSB PDB 1QAG · PDBe 1QAG · UniProt P46939
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