Research workbench
Rabies virus glycoprotein in complex with Fab fragments of 17C7 and 1112-1 neutralizing antibodies
Analyse Rabies virus glycoprotein in complex with Fab fragments of 17C7 and 1112-1… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 8A1E
- Type
- protein
- Length
- 790 residues
- Chains
- 5
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glycoprotein; Fab 17C7 heavy chain variable domain; Fab 17C7 light chain variable domain…
- UniProt
- P08667
- Pockets
- 11 · best druggability 0.80
Structure
electron microscopy · 5 distinct chains · 9% helix, 38% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Glycoprotein | protein | 344 | 16% helix, 28% strand | P08667 |
| D | Fab 17C7 heavy chain variable domain | protein | 119 | 5% helix, 49% strand | — |
| E | Fab 17C7 light chain variable domain | protein | 109 | 3% helix, 50% strand | — |
| C | Fab 1112-1 light chain variable domain | protein | 101 | 0% helix, 39% strand | — |
| B | Fab 1112-1 heavy chain variable domain | protein | 117 | 3% helix, 45% strand | — |
Pockets
11 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 812 | 0.80 | 0.83 | 89 | empty |
| 2 | 593 | 0.67 | 0.77 | 57 | empty |
| 3 | 53 | 0.53 | 0.89 | 16 | empty |
| 4 | 84 | 0.48 | 0.82 | 14 | empty |
| 5 | 121 | 0.45 | 0.77 | 24 | empty |
Interfaces
8 interfaces between chains.
- D–E · 877 Ų buried · 7 hydrogen bonds · protein-protein
- C–B · 794 Ų buried · 3 hydrogen bonds · protein-protein
- A–B · 761 Ų buried · 20 hydrogen bonds · protein-protein
- A–D · 684 Ų buried · 7 hydrogen bonds · protein-protein
- A–E · 433 Ų buried · 4 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 11 disulfide (disulfide).
Compared structures
- 8A1E · Rabies virus glycoprotein in complex with Fab fragments of 17C7 and 1112-1 neutralizing… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P08667
- Elsewhere: RCSB PDB 8A1E · PDBe 8A1E · UniProt P08667
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