Research workbench
Crystal structure of YTHDF2 with compound YLI_DF_042
Analyse Crystal structure of YTHDF2 with compound YLI_DF_042 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7ZG4
- Type
- protein
- Length
- 296 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Yth domain-containing family protein 2
- UniProt
- Q9Y5A9
- Ligands
- IQL, SO4
- Pockets
- 2 · best druggability 0.53
Structure
x-ray diffraction · 2 distinct chains · 29% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Yth domain-containing family protein 2 | protein | 148 | 28% helix, 28% strand | Q9Y5A9 |
| B | Yth domain-containing family protein 2 | protein | 148 | 29% helix, 30% strand | Q9Y5A9 |
Ligands and binding sites
- IQL · N-methylpyrimidine-2-carboximidamide · ligand · 2 copies · chains A, B
- SO4 · Sulfate ion · ion · 5 copies · chains A, B
- GOL · Glycerol · additive · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 155 | 0.53 | 0.80 | 33 | SO4, IQL |
| 2 | 55 | 0.40 | 0.81 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 406 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 7ZG4 · Crystal structure of YTHDF2 with compound YLI_DF_042 · the same entry in another collection · chain A against A, TM-score 1.00
- Q9Y5A9 · AlphaFold monomer V2.0 prediction for yth domain-containing family protein 2 (Q9Y5A9) · a predicted model of the same protein · chain B against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9Y5A9
- Elsewhere: RCSB PDB 7ZG4 · PDBe 7ZG4 · UniProt Q9Y5A9
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