Research workbench

Human zn matcap

Analyse Human zn matcap in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7Z5H
Type: protein
Length: 1,323 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Uncharacterized protein KIAA0895-like
UniProt: Q68EN5
Ligands: ZN
Pockets: 9 · best druggability 0.81

Structure

x-ray diffraction · 3 distinct chains · 55% helix, 7% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Uncharacterized protein KIAA0895-like	protein	332	55% helix, 7% strand	Q68EN5
B, C	Uncharacterized protein KIAA0895-like	protein	330	55% helix, 7% strand	Q68EN5
D	Uncharacterized protein KIAA0895-like	protein	331	56% helix, 7% strand	Q68EN5

Ligands and binding sites

ZN · Zinc ion · metal · 4 copies · chains A, B, C, D

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

9 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	935	0.81	0.83	72	empty
2	989	0.81	0.82	72	ZN
3	1115	0.78	0.80	93	empty
4	1178	0.77	0.79	88	empty
5	849	0.70	0.76	77	empty

Interfaces

4 interfaces between chains.

C–D · 805 Å² buried · 11 hydrogen bonds · protein-protein
B–C · 605 Å² buried · 7 hydrogen bonds · protein-protein
A–B · 602 Å² buried · 5 hydrogen bonds · protein-protein
A–D · 422 Å² buried · 4 hydrogen bonds · protein-protein

Compared structures

7Z5H · human Zn MATCAP · the same entry in another collection · chain A against A, TM-score 1.00
Q68EN5 · AlphaFold monomer V2.0 prediction for uncharacterized protein KIAA0895-like (Q68EN5) · a predicted model of the same protein · chain B against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q68EN5
Elsewhere: RCSB PDB 7Z5H · PDBe 7Z5H · UniProt Q68EN5

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