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Crystal structure of aldehyde dehydrogenase 1A1 from mouse
Analyse Crystal structure of aldehyde dehydrogenase 1A1 from mouse in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7YOB
- Type
- protein
- Length
- 3,950 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Aldehyde dehydrogenase 1A1
- EC
- 1.2.1.19, 1.2.1.28, 1.2.1.3, 1.2.1.36
- UniProt
- P24549
- Pockets
- 20 · best druggability 0.90
Structure
x-ray diffraction · 2 distinct chains · 40% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, H, F | Aldehyde dehydrogenase 1A1 (EC 1.2.1.19, 1.2.1.28, 1.2.1.3, 1.2.1.36) | protein | 494 | 40% helix, 22% strand | P24549 |
| G | Aldehyde dehydrogenase 1A1 (EC 1.2.1.19, 1.2.1.28, 1.2.1.3, 1.2.1.36) | protein | 492 | 39% helix, 22% strand | P24549 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1054 | 0.90 | 0.92 | 94 | empty |
| 2 | 1126 | 0.90 | 0.92 | 137 | empty |
| 3 | 861 | 0.82 | 0.84 | 126 | empty |
| 4 | 143 | 0.80 | 0.97 | 33 | empty |
| 5 | 125 | 0.79 | 0.98 | 33 | empty |
Interfaces
15 interfaces between chains.
- A–D · 2762 Ų buried · 36 hydrogen bonds · protein-protein
- E–F · 2744 Ų buried · 40 hydrogen bonds · protein-protein
- B–C · 2721 Ų buried · 35 hydrogen bonds · protein-protein
- G–H · 2659 Ų buried · 31 hydrogen bonds · protein-protein
- A–C · 1545 Ų buried · 36 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P24549
- Elsewhere: RCSB PDB 7YOB · PDBe 7YOB · UniProt P24549
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