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An engineered 5-helix bundle derived from SARS-cov-2 S2 in complex with HR2P

Analyse An engineered 5-helix bundle derived from SARS-cov-2 S2 in complex with HR2P in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7Y9N
Type: protein
Length: 244 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Spike protein S2',5HB-H2; SARS-cov-2 S2 subunit
UniProt: P0DTC2
Pockets: 1 · best druggability 0.74

Structure

x-ray diffraction · 2 distinct chains · 79% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Spike protein S2',5HB-H2	protein	212	83% helix, 0% strand	P0DTC2
B	SARS-cov-2 S2 subunit	protein	32	53% helix, 0% strand	P0DTC2

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	62	0.74	0.99	18	empty

Interfaces

1 interface between chains.

A–B · 1631 Å² buried · 29 hydrogen bonds · protein-protein

Compared structures

7Y9N · an engineered 5-helix bundle derived from SARS-CoV-2 S2 in complex with HR2P · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P0DTC2
Elsewhere: RCSB PDB 7Y9N · PDBe 7Y9N · UniProt P0DTC2

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