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24B3 antibody-peptide complex

Analyse 24B3 antibody-peptide complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7Y3J
Type: protein
Length: 447 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 24B3 light chain; 24B3 heavy chain; Ala-leu-val-phe-phe-ala-pro-ala-val-gly-ser
Pockets: 5 · best druggability 0.59

Structure

x-ray diffraction · 3 distinct chains · 6% helix, 50% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
L	24B3 light chain	protein	217	6% helix, 52% strand	—
H	24B3 heavy chain	protein	219	7% helix, 50% strand	—
A	Ala-leu-val-phe-phe-ala-pro-ala-val-gly-ser	protein	11	0% helix, 9% strand	—

Pockets

5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	488	0.59	0.74	58	empty
2	151	0.46	0.76	20	empty
3	127	0.42	0.75	21	empty
4	84	0.37	0.76	17	empty
5	53	0.25	0.73	19	empty

Interfaces

3 interfaces between chains.

L–H · 1872 Å² buried · 18 hydrogen bonds · protein-protein
H–A · 412 Å² buried · 4 hydrogen bonds · protein-protein
L–A · 371 Å² buried · 3 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

7Y3J · 24B3 antibody-peptide complex · the same entry in another collection · chain L against L, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 7Y3J · PDBe 7Y3J

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