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Crystal structure of daucus carrot hypoglycemic peptide (dchp)

Analyse Crystal structure of daucus carrot hypoglycemic peptide (dchp) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7XKC
Type: protein
Length: 331 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Dchp
UniProt: A0A166C3G6
Ligands: SO4
Pockets: 6 · best druggability 0.59

Structure

x-ray diffraction · 3 distinct chains · 17% helix, 37% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Dchp	protein	84	17% helix, 37% strand	A0A166C3G6
B	Dchp	protein	77	18% helix, 38% strand	A0A166C3G6
C, D	Dchp	protein	85	16% helix, 36% strand	A0A166C3G6

Ligands and binding sites

SO4 · Sulfate ion · ion · 3 copies · chains A, B, D, C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	342	0.59	0.77	45	SO4
2	180	0.53	0.79	26	empty
3	104	0.51	0.82	18	empty
4	199	0.50	0.76	29	empty
5	148	0.47	0.77	24	empty

Interfaces

3 interfaces between chains.

A–C · 958 Å² buried · 11 hydrogen bonds · protein-protein
B–D · 823 Å² buried · 14 hydrogen bonds · protein-protein
A–B · 551 Å² buried · 7 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

7XKC · Crystal structure of Daucus Carrot hypoglycemic peptide (DCHP) · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A166C3G6
Elsewhere: RCSB PDB 7XKC · PDBe 7XKC · UniProt A0A166C3G6

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