Research workbench
Transcription factor STAT3B/DNA complex
Analyse Transcription factor STAT3B/DNA complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1BG1
- Type
- protein + DNA
- Length
- 577 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- DNA (5'- D(*TP*GP*CP*AP*TP*TP*TP*CP*CP*CP*GP*TP*AP*AP*AP*TP*CP*T)- 3'); Protein…
- UniProt
- P42227
- Pockets
- 7 · best druggability 0.58
Structure
x-ray diffraction · 2 distinct chains · 43% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | DNA (5'- D(*TP*GP*CP*AP*TP*TP*TP*CP*CP*CP*GP*TP*AP*AP*AP*TP*CP*T)- 3') | dna | 18 | — | — |
| A | Protein (transcription factor STAT3B) | protein | 559 | 43% helix, 15% strand | P42227 |
Pockets
7 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 267 | 0.58 | 0.78 | 41 | empty |
| 2 | 141 | 0.49 | 0.79 | 24 | empty |
| 3 | 193 | 0.48 | 0.75 | 22 | empty |
| 4 | 139 | 0.46 | 0.77 | 19 | empty |
| 5 | 62 | 0.44 | 0.82 | 16 | empty |
Interfaces
1 interface between chains.
- B–A · 330 Ų buried · 7 hydrogen bonds · protein-nucleic
Modifications
Observed in the structure: 1 modified (phosphorylation).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P42227
- Elsewhere: RCSB PDB 1BG1 · PDBe 1BG1 · UniProt P42227
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