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Cobalamin-dependent methionine synthase (1-566) from T. maritima (oxidized, orthorhombic)
Analyse Cobalamin-dependent methionine synthase (1-566) from T. maritima (oxidized… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1Q7Q
- Type
- protein
- Length
- 1,117 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 5-methyltetrahydrofolate S-homocysteine methyltransferase
- EC
- 2.1.1.13
- UniProt
- Q9WYA5
- Pockets
- 12 · best druggability 0.62
Structure
x-ray diffraction · 2 distinct chains · 46% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 5-methyltetrahydrofolate S-homocysteine methyltransferase (EC 2.1.1.13) | protein | 565 | 46% helix, 13% strand | Q9WYA5 |
| B | 5-methyltetrahydrofolate S-homocysteine methyltransferase (EC 2.1.1.13) | protein | 552 | 45% helix, 13% strand | Q9WYA5 |
Pockets
12 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 246 | 0.62 | 0.81 | 34 | empty |
| 2 | 271 | 0.61 | 0.79 | 36 | empty |
| 3 | 128 | 0.54 | 0.82 | 15 | empty |
| 4 | 246 | 0.51 | 0.76 | 34 | empty |
| 5 | 118 | 0.49 | 0.80 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 1078 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 1Q7Q · Cobalamin-dependent methionine synthase (1-566) from T. maritima (Oxidized, Orthorhombic) · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9WYA5
- Elsewhere: RCSB PDB 1Q7Q · PDBe 1Q7Q · UniProt Q9WYA5
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