Research workbench
Cobalamin-dependent methionine synthase (meth) from thermotoga maritima (oxidized, monoclinic)
Analyse Cobalamin-dependent methionine synthase (meth) from thermotoga maritima… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1Q7M
- Type
- protein
- Length
- 1,107 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 5-methyltetrahydrofolate S-homocysteine methyltransferase
- EC
- 2.1.1.13
- UniProt
- Q9WYA5
- Pockets
- 7 · best druggability 0.64
Structure
x-ray diffraction · 2 distinct chains · 47% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 5-methyltetrahydrofolate S-homocysteine methyltransferase (EC 2.1.1.13) | protein | 559 | 47% helix, 15% strand | Q9WYA5 |
| B | 5-methyltetrahydrofolate S-homocysteine methyltransferase (EC 2.1.1.13) | protein | 548 | 47% helix, 13% strand | Q9WYA5 |
Pockets
7 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 304 | 0.64 | 0.80 | 37 | empty |
| 2 | 304 | 0.62 | 0.79 | 45 | empty |
| 3 | 337 | 0.58 | 0.77 | 37 | empty |
| 4 | 258 | 0.50 | 0.75 | 30 | empty |
| 5 | 131 | 0.49 | 0.79 | 23 | empty |
Interfaces
1 interface between chains.
- A–B · 1103 Ų buried · 1 hydrogen bond · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 1Q7M · Cobalamin-dependent methionine synthase (MetH) from Thermotoga maritima (Oxidized… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9WYA5
- Elsewhere: RCSB PDB 1Q7M · PDBe 1Q7M · UniProt Q9WYA5
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