Research workbench
Structure of a membrane protein G
Analyse Structure of a membrane protein G in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7WSO
- Type
- protein
- Length
- 780 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Immunoglobulin heavy constant gamma 1; B-cell antigen receptor complex-associated protein…
- UniProt
- A0A0A0MS08, P11912, P40259
- Pockets
- 10 · best druggability 0.79
Structure
electron microscopy · 3 distinct chains · 19% helix, 34% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| K, B | Immunoglobulin heavy constant gamma 1 | protein | 252 | 15% helix, 38% strand | A0A0A0MS08 |
| A | B-cell antigen receptor complex-associated protein alpha chain | protein | 137 | 21% helix, 26% strand | P11912 |
| C | B-cell antigen receptor complex-associated protein beta chain | protein | 139 | 24% helix, 33% strand | P40259 |
Pockets
10 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1019 | 0.79 | 0.81 | 100 | empty |
| 2 | 129 | 0.62 | 0.86 | 21 | empty |
| 3 | 136 | 0.55 | 0.81 | 26 | empty |
| 4 | 110 | 0.54 | 0.83 | 21 | empty |
| 5 | 149 | 0.51 | 0.79 | 26 | empty |
Interfaces
6 interfaces between chains.
- K–B · 1980 Ų buried · 3 hydrogen bonds · protein-protein
- A–C · 1299 Ų buried · 8 hydrogen bonds · protein-protein
- B–C · 1230 Ų buried · 8 hydrogen bonds · protein-protein
- K–A · 1113 Ų buried · 6 hydrogen bonds · protein-protein
- A–B · 788 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 8 disulfide (disulfide).
Compared structures
- 7WSO · Structure of a membrane protein G · the same entry in another collection · chain K against K, TM-score 1.00
- P40259 · AlphaFold monomer V2.0 prediction for B-cell antigen receptor complex-associated protein… · a predicted model of the same protein · chain C against A, TM-score 0.73
- P11912 · AlphaFold monomer V2.0 prediction for B-cell antigen receptor complex-associated protein… · a predicted model of the same protein · chain A against A, TM-score 0.67
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A0A0MS08
- Every structure of UniProt P11912
- Every structure of UniProt P40259
- Elsewhere: RCSB PDB 7WSO · PDBe 7WSO · UniProt A0A0A0MS08 · UniProt P11912 · UniProt P40259
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