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Cryo-EM structure of ATSLAC1 S59A mutant

Analyse Cryo-EM structure of ATSLAC1 S59A mutant in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7WNQ
Type: protein
Length: 1,104 residues
Chains: 3
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Guard cell S-type anion channel SLAC1
UniProt: Q9LD83
Pockets: 20 · best druggability 0.83

Structure

electron microscopy · 1 distinct chain · 64% helix, 2% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C	Guard cell S-type anion channel SLAC1	protein	368	64% helix, 2% strand	Q9LD83

Pockets

20 pockets found on a 1 Å grid, 11 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	856	0.83	0.84	62	empty
2	559	0.73	0.80	54	empty
3	559	0.72	0.80	57	empty
4	556	0.72	0.80	64	empty
5	51	0.66	0.96	15	empty

Interfaces

3 interfaces between chains.

A–C · 1233 Å² buried · 9 hydrogen bonds · protein-protein
A–B · 1222 Å² buried · 8 hydrogen bonds · protein-protein
B–C · 1217 Å² buried · 8 hydrogen bonds · protein-protein

Compared structures

7WNQ · Cryo-EM structure of AtSLAC1 S59A mutant · the same entry in another collection · chain A against A, TM-score 1.00
Q9LD83 · AlphaFold monomer V2.0 prediction for guard cell S-type anion channel SLAC1 (Q9LD83) · a predicted model of the same protein · chain A against A, TM-score 0.92

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9LD83
Elsewhere: RCSB PDB 7WNQ · PDBe 7WNQ · UniProt Q9LD83

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