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Cryo-EM structure of GH31 alpha-1,3-glucosidase from lactococcus lactis subsp. cremoris
Analyse Cryo-EM structure of GH31 alpha-1,3-glucosidase from lactococcus lactis subsp.… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7WLG
- Type
- protein
- Length
- 4,368 residues
- Chains
- 6
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Alpha-xylosidase
- EC
- 3.2.1.-
- UniProt
- A2RM80
- Pockets
- 20 · best druggability 0.78
Structure
electron microscopy · 1 distinct chain · 27% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F | Alpha-xylosidase (EC 3.2.1.-) | protein | 728 | 27% helix, 23% strand | A2RM80 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1017 | 0.78 | 0.80 | 99 | empty |
| 2 | 981 | 0.77 | 0.80 | 100 | empty |
| 3 | 968 | 0.77 | 0.80 | 91 | empty |
| 4 | 836 | 0.77 | 0.80 | 54 | empty |
| 5 | 887 | 0.77 | 0.80 | 88 | empty |
Interfaces
12 interfaces between chains.
- B–F · 1334 Ų buried · 10 hydrogen bonds · protein-protein
- C–E · 1334 Ų buried · 7 hydrogen bonds · protein-protein
- A–D · 1333 Ų buried · 6 hydrogen bonds · protein-protein
- C–F · 835 Ų buried · 7 hydrogen bonds · protein-protein
- B–D · 831 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 7WLG · Cryo-EM structure of GH31 alpha-1,3-glucosidase from Lactococcus lactis subsp. cremoris · the same entry in another collection · chain B against B, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A2RM80
- Elsewhere: RCSB PDB 7WLG · PDBe 7WLG · UniProt A2RM80
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