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2.2 ångströms resolution structure analysis of two refined N- acetylneuraminyllactose-wheat germ agglutinin isolectin complexes

Analyse 2.2 ångströms resolution structure analysis of two refined N… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7WGA
Type: protein
Length: 342 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Wheat germ lectin
UniProt: P10968
Pockets: 1 · best druggability 0.61

Structure

x-ray diffraction · 1 distinct chain · 19% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Wheat germ lectin	protein	171	19% helix, 16% strand	P10968

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	422	0.61	0.77	58	empty

Interfaces

1 interface between chains.

A–B · 228 Å² buried · 2 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 32 disulfide, 2 modified (disulfide, cyclization).

Compared structures

7WGA · 2.2 ångströms resolution structure analysis of two refined… · the same entry in another collection · chain A against A, TM-score 1.00
P10968 · AlphaFold monomer V2.0 prediction for agglutinin isolectin 1 (P10968) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P10968
Elsewhere: RCSB PDB 7WGA · PDBe 7WGA · UniProt P10968

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