Research workbench
Structure of american mink ACE2
Analyse Structure of american mink ACE2 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7WA3
- Type
- protein
- Length
- 1,200 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Angiotensin-converting enzyme
- EC
- 3.4.-.-
- UniProt
- A0A7T0Q2W2
- Ligands
- NAG, FUC, ZN
- Pockets
- 7 · best druggability 0.71
Structure
x-ray diffraction · 1 distinct chain · 62% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Angiotensin-converting enzyme (EC 3.4.-.-) | protein | 600 | 62% helix, 4% strand | A0A7T0Q2W2 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 6 copies · chains B, A
- FUC · alpha-L-fucopyranose · sugar
- ZN · Zinc ion · metal · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 907 | 0.71 | 0.76 | 70 | empty |
| 2 | 674 | 0.69 | 0.77 | 53 | empty |
| 3 | 761 | 0.67 | 0.75 | 73 | empty |
| 4 | 473 | 0.67 | 0.78 | 41 | empty |
| 5 | 495 | 0.66 | 0.78 | 45 | empty |
Interfaces
1 interface between chains.
- A–B · 234 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 disulfide, 5 glycan (disulfide, N-glycosylation).
Compared structures
- 7WA3 · Structure of American mink ACE2 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A7T0Q2W2
- Elsewhere: RCSB PDB 7WA3 · PDBe 7WA3 · UniProt A0A7T0Q2W2
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