Research workbench
Crystal structure of shaft pilin pitb from pilus islet-2 of streptococcus oralis
Analyse Crystal structure of shaft pilin pitb from pilus islet-2 of streptococcus oralis in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7W7I
- Type
- protein
- Length
- 2,375 residues
- Chains
- 7
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fcta domain-containing protein
- UniProt
- D4FSQ5
- Pockets
- 8 · best druggability 0.80
Structure
x-ray diffraction · 7 distinct chains · 0% helix, 42% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Fcta domain-containing protein | protein | 341 | 0% helix, 42% strand | D4FSQ5 |
| B | Fcta domain-containing protein | protein | 342 | 0% helix, 42% strand | D4FSQ5 |
| C | Fcta domain-containing protein | protein | 341 | 0% helix, 41% strand | D4FSQ5 |
| D | Fcta domain-containing protein | protein | 339 | 0% helix, 42% strand | D4FSQ5 |
| E | Fcta domain-containing protein | protein | 338 | 1% helix, 43% strand | D4FSQ5 |
| F | Fcta domain-containing protein | protein | 340 | 0% helix, 43% strand | D4FSQ5 |
| G | Fcta domain-containing protein | protein | 334 | 0% helix, 41% strand | D4FSQ5 |
Pockets
8 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 145 | 0.80 | 0.96 | 31 | empty |
| 2 | 114 | 0.76 | 0.95 | 33 | empty |
| 3 | 69 | 0.73 | 0.97 | 20 | empty |
| 4 | 90 | 0.73 | 0.95 | 36 | empty |
| 5 | 204 | 0.59 | 0.81 | 25 | empty |
Interfaces
6 interfaces between chains.
- A–B · 677 Ų buried · 7 hydrogen bonds · protein-protein
- B–D · 666 Ų buried · 8 hydrogen bonds · protein-protein
- C–F · 618 Ų buried · 4 hydrogen bonds · protein-protein
- D–F · 552 Ų buried · 6 hydrogen bonds · protein-protein
- E–G · 544 Ų buried · 6 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 13 isopeptide (isopeptide).
Compared structures
- 7W7I · Crystal Structure of shaft pilin PitB from pilus islet-2 of Streptococcus oralis · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt D4FSQ5
- Elsewhere: RCSB PDB 7W7I · PDBe 7W7I · UniProt D4FSQ5
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