Research workbench
Human dutp pyrophosphatase
Analyse Human dutp pyrophosphatase in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1Q5U
- Type
- protein
- Length
- 390 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Dutp pyrophosphatase
- UniProt
- P33316
- Pockets
- 4 · best druggability 0.80
Structure
x-ray diffraction · 3 distinct chains · 5% helix, 45% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| X | Dutp pyrophosphatase | protein | 131 | 5% helix, 45% strand | P33316 |
| Y | Dutp pyrophosphatase | protein | 127 | 6% helix, 46% strand | P33316 |
| Z | Dutp pyrophosphatase | protein | 132 | 5% helix, 44% strand | P33316 |
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 144 | 0.80 | 0.97 | 30 | empty |
| 2 | 138 | 0.46 | 0.77 | 27 | empty |
| 3 | 144 | 0.43 | 0.75 | 26 | empty |
| 4 | 135 | 0.42 | 0.75 | 29 | empty |
Interfaces
3 interfaces between chains.
- X–Y · 1776 Ų buried · 29 hydrogen bonds · protein-protein
- X–Z · 1692 Ų buried · 27 hydrogen bonds · protein-protein
- Y–Z · 1690 Ų buried · 21 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P33316
- Elsewhere: RCSB PDB 1Q5U · PDBe 1Q5U · UniProt P33316
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