Research workbench
The crystal structure of human forkhead box protein in complex with DNA 1
Analyse The crystal structure of human forkhead box protein in complex with DNA 1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7VOU
- Type
- protein + DNA
- Length
- 118 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- DNA (5'-D(*AP*CP*TP*TP*GP*TP*TP*TP*AP*CP*AP*TP*TP*TP*TP*G)- 3'); DNA…
- UniProt
- P58012
- Pockets
- 3 · best druggability 0.38
Structure
x-ray diffraction · 3 distinct chains · 50% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | DNA (5'-D(*AP*CP*TP*TP*GP*TP*TP*TP*AP*CP*AP*TP*TP*TP*TP*G)- 3') | dna | 16 | — | — |
| B | DNA (5'-D(*CP*AP*AP*AP*AP*TP*GP*TP*AP*AP*AP*CP*AP*AP*GP*T)- 3') | dna | 16 | — | — |
| C | Forkhead box protein L2 | protein | 86 | 50% helix, 12% strand | P58012 |
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 66 | 0.38 | 0.79 | 12 | empty |
| 2 | 118 | 0.37 | 0.74 | 18 | empty |
| 3 | 113 | 0.37 | 0.75 | 14 | empty |
Interfaces
3 interfaces between chains.
- A–B · 641 Ų buried · 54 hydrogen bonds · nucleic-nucleic
- A–C · 516 Ų buried · 9 hydrogen bonds · protein-nucleic
- B–C · 395 Ų buried · 5 hydrogen bonds · protein-nucleic
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 7VOU · The crystal structure of human forkhead box protein in complex with DNA 1 · the same entry in another collection · chain A against A, TM-score 1.00
- P58012 · AlphaFold monomer V2.0 prediction for forkhead box protein L2 (P58012) · a predicted model of the same protein · chain C against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P58012
- Elsewhere: RCSB PDB 7VOU · PDBe 7VOU · UniProt P58012
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