Research workbench
The crystal structure of the bifunctional primase-helicase of bacteriophage T7
Analyse The crystal structure of the bifunctional primase-helicase of bacteriophage T7 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1Q57
- Type
- protein
- Length
- 3,381 residues
- Chains
- 7
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- DNA PRIMASE/HELICASE
- EC
- 2.7.7.-
- UniProt
- P03692
- Pockets
- 20 · best druggability 0.81
Structure
x-ray diffraction · 1 distinct chain · 33% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G | DNA PRIMASE/HELICASE (EC 2.7.7.-) | protein | 483 | 33% helix, 23% strand | P03692 |
Pockets
20 pockets found on a 1 Å grid, 15 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 698 | 0.81 | 0.85 | 72 | empty |
| 2 | 1168 | 0.81 | 0.82 | 112 | empty |
| 3 | 1056 | 0.81 | 0.82 | 94 | empty |
| 4 | 381 | 0.80 | 0.90 | 52 | empty |
| 5 | 1078 | 0.80 | 0.82 | 92 | empty |
Interfaces
7 interfaces between chains.
- F–G · 2024 Ų buried · 23 hydrogen bonds · protein-protein
- B–G · 1972 Ų buried · 30 hydrogen bonds · protein-protein
- C–D · 1851 Ų buried · 31 hydrogen bonds · protein-protein
- D–E · 1754 Ų buried · 28 hydrogen bonds · protein-protein
- A–B · 1673 Ų buried · 21 hydrogen bonds · protein-protein
Compared structures
- 1Q57 · The Crystal Structure of the Bifunctional Primase-Helicase of Bacteriophage T7 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03692
- Elsewhere: RCSB PDB 1Q57 · PDBe 1Q57 · UniProt P03692
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.